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The molecular design was based on the SAR features of indolin-2-ones as kinase inhibitors.
IBE-667 was designed based on the SAR information obtained from an on-bead screen of tagged one-bead one-compound combinatorial libraries by confocal nanoscanning and bead picking (CONA).
Based on the SAR exploration, the original lead (3) and the most potent agonists on hSUCNR1 (31) and mSUCNR1 (21) were selected for further property investigations.
Based on the SAR information obtained from the above study, five new compounds were designed and subsequently synthesized.
Based on the SAR, the most potent (in vitro) α1 selective ligand was the 6-substituted acetylenyl βCCt (WYS8, 7).
A novel series of compounds containing a polar, non-flat 2-imidazoline core was designed based on the SAR information available for aromatic azole cyclooxygenase-2 inhibitors.
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Future work will deal with more complex target models and the development of associated imaging algorithms based on the monostatic SAR processors presented in [19, 20] where subspace approaches are used to integrate complex target model in monostatic SAR processing.
(2) The second simulation experiment is based on the traditional SAR signal PTRS model, which is developed under stop-and-go approximation.
According to the three steps in CS theory, in [3], DWT was utilized to make SAR imagery sparse and the random Gauss matrix after approximate QR decomposition was employed to complete the low-dimension measurement for sparse results based on the original SAR imagery divided into several sub-imageries.
To extract more detailed topographic features, a DEM of the study area was generated based on the Interferometric SAR (InSAR) technique, using an ERS-1 image pair (path 269, row 438) at the ascending mode; the images were acquired 3 days apart (7 and 10 December 1991) with a 146 m perpendicular baseline.
Further optimization can follow different routes, but most are based on the traditional SAR in which individual "scaffolds" (each of the non-natural amino acids) are iteratively optimized.
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