In this paper, the multidimensional construct of NRBD perceived risk was preliminarily developed based on the grounded theory, the reasonableness of the multidimensional construct was verified through empirical analysis, and the measurement scale was finally determined.
The best docking solution, mostly based on the value of the Autodock Intermolecular Energy parameter and the reasonableness of the interactions between the ligand and the protein, was used for the construction of the PZA-PncA acyl-enzyme intermediate which was further energy-minimized (100 steps) using the minimization module of CNS [21].
We continue by proposing an alternative approach based on the combination of two innovative and increasingly important frameworks for health care priority setting: accountability for reasonableness (A4R) to foster fair priority setting processes, and multi-criteria decision analysis (MCDA) to foster rational priority setting.
Second, an incentive mechanism for allocating TPPDC is proposed based on the uniform price auction of divisible goods, and an evaluation model to evaluate the validity for the free allocation of TPPDC is established, and the feasibility and reasonableness of this evaluation model are proved.
Given this, the multidimensional construct of perceived risk of NRBD based on the grounded theory should be further verified through exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) to prove its reasonableness.
Based on the findings from this study, our previous study of the OWTS [ 22], current public involvement literature, and the 'accountability for reasonableness' framework we suggest concrete ways for improving public engagement in wait time management in Table 2: Recommendations for Public Engagement in the Ontario Wait Time Strategy.
This is acknowledged by the 'Accountability for Reasonableness' (A4R) framework [ 2, 3] which is based on the believe that any consensus on priority setting weights and subsequent results may be difficult to achieve because of these distinct perspectives of stakeholders.
Based on the findings, the Dutch researchers formulated a normative multidimensional understanding of the principle, where four moral concepts are relevant, namely protection of freedom, reasonableness, people's choices as part of their life story and the moral element of care as being essential parts of respect for autonomy.
For instance, it might be based on standards of reasonableness or fairness developed by judges in contract or administrative law.
In On the Reasonableness of Christianity (1695), Locke aims to establish the compatibility of reason and the teachings of Christianity.
