The entertainment value of "Das Experiment" is based on the genetic predisposition toward bullying machismo, and the fact that the role of guard will ultimately pull anyone into the undertow.
A severity assessment score based on the PIRO (Predisposition, Insult, Response, and Organ dysfunction) concept was assessed, including comorbidities, age greater than 70 years, multilobar opacities in chest x-ray, shock, severe hypoxemia, acute renal failure, bacteremia, and acute respiratory distress syndrome.
Multiple ICU prediction rules have been proposed including the Infectious Disease Society of America/American Thoracic Society (IDSA/ATS) criteria, the SMART-COP and scores based on the PIRO (Predisposition, insult/infection, response, and organ dysfunction) concept [ 56- 60].
In the adjuvant setting, the choice of treatment regimen is not modified based on the presence of such a predisposition.
As the shared epitope in human leukocyte antigen-DR genes is found in about 80% of RA patients, dysregulated CD4+ T cell activation and function have been investigated based on the available evidence of genetic predisposition [ 2, 3].
For the purpose to improve our understanding of the PTC predisposition, based on the recent progresses in genetic studies about PTC, we analyzed in this Chinese family (1) the point mutations of the BRAF and RET; (2) the possible susceptibility loci to sporadic PTC; and (3) the suggested potential fMNG syndrome with PTC risk region.
Based on the higher frequencies of well-known predispositions identified by traditional approaches, the rarity of the predispositions recently identified by population-based approach, and the presence of family-specific, novel, deleterious variants in disease families revealed in our study, we propose a model to explain the genetic predispositions in familial breast cancer.
The genetic predisposition to RA, based on the polymorphic HLA-DRB1 locus, which was carried by an early case known as the 'Braids Lady' from Arezzo (Italy), combined with pathomorphological lesions characteristic for this condition.
A genetic predisposition to diabetic nephropathy based on the DD genotype has been reported in several studies [32] [34], but remains controversial [35].
If we care about diversity, we must all strive to counter our own predisposition to develop a bias based on the data we see.
