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We annotated the functionally characterized genes based on the phenotypes described in each of the articles (Table 1).
Previously, two other histone H3K36 demethylases (Jmjd5 or Fbxl10) were analyzed based on the phenotypes of the corresponding knockout (KO) mice; the results of those studies implicated H3K36 demethylases in cell proliferation, apoptosis, and senescence (Fukuda et al., 2011; Ishimura et al., 2012).
We compare strain similarity based on the phenotypes with genotypic relatedness computed from genomic SNP profiles.
Finally, we observe little concordance between strain similarity based on the phenotypes and genotypic relatedness computed from genomic SNP profiles.
Based on the phenotypes resulting from its knockout, several cellular roles for the translocon β subunit have been proposed.
Based on the phenotypes of zebrafish and Xenopus embryos injected with synthetic mRNA, zebrafish wnt4a and Xenopus Xwnt-5A appear to share a similar function, distinct from that of wnt1, Xwnt3A and Xwnt8 [16].
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In contrast, under the positive phenotypic assortment model mate selection is purely based on the phenotype of the spouses (i.e., similar general intelligence).
Based on the phenotype description of slr1 mutants by Ikeda et al. (2001) we were indeed expecting a constitutive gibberellin response that leads to a tall phenotype.
The strains were clustered based on the phenotype scores obtained, using the Pearson correlation and UPGMA clustering (Spotfire 4.5 – TIBCO Software Inc., 2007 2012, Somerville, Massachusetts, USA).
Based on the phenotype, macrophages are classified into classically activated/(M1) and alternatively activated/(M2) which are further sub-categorized into M2a, M2b, M2c and M2d based upon gene expression profiles.
Detailed description and classification of the positive hits into groups based on the phenotype is presented in Table S2.
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