We suggest that VP35 may be the likely target based on the overlap of receptor-based pharmacophores and docking into the crystal structure.
However, when the overlapped transcripts are isolated into sets based on the overlap percentage, the expression profiles determined by the two protocols become less and less correlated with the increase of the overlap percentage, real).
Such relationships were extracted by first calculating the conditional overlap values (e.g. P(i|j), P j|i)) for all region pairs, then by classifying each region pair as belonging to one of the possible logical relationships based on the overlap pair.
The TG-based type has four performance indices which are based on the overlap of a PCTFP's target genes, the expression coherence of a PCTFP's common target genes, the functional coherence of a PCTFP's common target genes, and the PPI coherence of a PCTFP's common target genes.
Based on the overlap in pathogenic pathways reported in the molecular studies 44 and the overlapping associations of some the genetic variants in genome-wide association studies of COPD and lung cancer, 45 the authors favor a causal relationship.
For the 8 community-cluster pairs we obtained, the P-value was calculated based on the overlap of each community with the targets of one thousand simulated miRNA clusters of the same size.
The biological coherence is calculated based on the overlap of GO annotations among all the genes falling into one cluster.
Targets are compared based on the overlap of common pharmacophoric pattern (RG MCSs) of the corresponding inSARa networks.
Molecular shape or volume approaches try to maximize the overlap of shapes or volumes and determine a similarity value based on the overlap.
The evaluation results from the proposed methodology were compared to the results that used a methodology based on the Overlap measure under equivalent test conditions.
The validation of the proposed methodology was performed by comparing its results with the results of a methodology based on the Overlap measure.
