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The "Natural" geographic distribution is based on the naturally occurring distribution of the Harvard Pilgrim Health Care (HPHC) members, whereas, the "Uniform" distribution draws members uniformly across the same geographic areas.
That strain is based on the naturally occurring soil bacterium Bacillus thuringiensis and mimics its production of a toxin to kill pests.
A novel pyrrolobenzodiazepine dimer payload, SG3227, was rationally designed based on the naturally occurring antitumour compound sibiromycin.
Each of these hemoglobin expression systems consists of Saccharomyces cerevisiae cells containing plasmids based on the naturally occurring yeast 2μ plasmid.
The most recent technology platform for delivering a targeted DSB to cellular genomes is that of the RNA-guided nucleases, which are based on the naturally occurring Type II prokaryotic CRISPR-Cas9 system.
In this study, we report the effects of a series of novel furanocoumarins based on the naturally occurring derivative 8-geranylepoxypsoralen which has been shown to be a more potent inhibitor of CYP3A4 than its 5-position-substituted counterpart bergamottin [Drug Metab. Dispos. 2000, 28, 766 771; Jpn. J. Pharmacol. 2000, 82, 122 129].
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The kinetics results, in general, are consistent with hypothesized results based on the naturally-occurring distribution of Idh-1 allele frequencies and previous fitness data [ 14].
The formation of a series of analogs containing a pyridine moiety in place of the natural thiazole heterocycle, based on the potent, naturally occurring HDAC inhibitor Largazole has been accomplished.
However, this hyperplasticity may be made possible even in adulthood via molecular manipulations which reopen critical-period development opportunities based on the principles naturally occurring in critical periods and following brain injury (e.g. excitatory-inhibitory balance) (Bavelier et al., 2010; Kuhlman et al., 2013; Nahmani and Turrigiano, 2014).
In this case, lineages reflect variations in mitochondrial DNA, dated through a genetic clock based on the rate of naturally occurring mutation.
Ideally, these customized synthetic biological systems and organisms would be much safer and less complicated than approaches based on the manipulation of naturally occurring biological entities.
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