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One may posit an explanation based on the markedly higher stability of the entire LdcI RavA complex compared to the LdcI-LARA complex: the scaffold provided by the AAA+ hub and the triple helical legs of RavA is required to glue the LARA domain in place and effectively preclude ppGpp binding.
On the basis of these results and based on the markedly increased number of lysosomes per ABCG2-overexpressing MDR A549/K1.5 cell, we further explored the hypothesis that MDR cells may consequently become highly sensitive to the cytotoxic effect elicited by IAs upon lysosomal photodestruction, resulting in the overcoming of MDR.
In particular, based on the markedly different targeting and phosphorylation of wild type LIMK1, compared to myr-SC and myr-CS LIMK1, we emphasize that palmitoylation is critical for targeting LIMK1 to spines and does not act as a simple membrane anchoring signal.
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Based on this markedly improved survival of ELBW infants, perhaps physicians should review the birth weight cut-off for NCPAP and INSURE, and offer this to all neonates with RDS, regardless of their birth weight.
The properties estimated using an analytical solution based on the Euler Bernoulli theory markedly deviated from experimental results for large apparent density values.
Based on the identification of genes markedly up-regulated during BDNF-induced synaptic consolidation in the hippocampus, we selected genetic variants that were tested in three independent samples, from Norway and Scotland, of adult individuals examined for cognitive abilities.
Based on the finding that IFN markedly decreases synthesis of collagen I and III, IFN has been suggested as an effective means for the improvement of excessive scars.
The reversal effect on the EMT was assumed based on the observation that etodolac markedly reduced the SNAIL mRNA expression and the vimentin cell surface expression and induced the E-cadherin mRNA expression and the E-cadherin cell surface expression, and also strongly inhibited cell migration in T24 cells.
In addition, the median standard error based on the observed information was markedly less than the standard deviation of bootstrap parameter estimates; this was particularly pronounced for the absolute sigmoid model, which was generally the best-fitting of the 2-parameter symmetric curve models.
In S. pseudintermedius, unlike E. coli and P. aeruginosa, orbifloxacin MICs against the mutants and MPCs against the original strains differed markedly based on the susceptibility of the original strain.
HIV's economic burden is predicted to grow markedly, based on the projected dramatic increase in the minority population as well as in HIV infections and complications associated with HAART [ 27].
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