Sentence examples for based on the lethality from inspiring English sources

Subjects were divided into two groups based on the lethality of the attempt according to the operational criteria of Beautrais [ 8], and subsequently analyzed.

We used deficiencies to map wellman to a 180 kb region in 93C1-D4 based on the lethality of both wel alleles in trans to Df 3R e-R1, but not Df 3R Exel6272 and Df 3R ED6058 (Parks et al., 2004; Ryder et al., 2007).

Alternatively, interpretations based on the supposed lethality of a self-harm may not give clear indications as to its intent: life risking behaviour may have no suicidal intent, whilst seemingly superficial cuts may have been a suicide attempt.

Based on the embryonic lethality of hep mutants it is obvious that Mkk4, which is expressed during embryonic development, cannot substitute for Hep function in this process.

The BRCA/PARP case has become the paradigm for a new class of rational cancer therapies based on the synthetic lethality concept [39 41].

This level of concern by the World Health Organization and other health-care authorities and providers is based on the high lethality of EBOV-Zaire in humans (up to 90%), its high communicability though body fluids, the high incidence of infection in primary health-care workers and the total lack of proven efficacious drugs or vaccines.

It has resulted in efficacy in mouse models of carcinogenesis that result from APC and KRAS mutations, and is being tested in breast cancer chemoprevention, based on the synthetic lethality between the mutated tumour suppressor genes BRCA1 or BRCA 2, and PARP1 (Fong et al, 2009).

One emerging class of therapeutic agents for this purpose is based on the principle of synthetic lethality.

This highlights the potential therapeutic benefit of PARP1 inhibitors, based on the hypothesis of synthetic lethality, in TN sporadic as well as BRCA1-mutated BC [ 47].

In BRCA-positive breast cancer, PARP inhibitors were found to increase the cytotoxic effects of radiation and chemotherapy based on the principle of synthetic lethality [ 43].

Inhibition of the DNA damage response proteins can be used to enhance chemotherapy and radiotherapy, and also to selectively kill cancer cells showing deficiencies in particular DNA repair pathway(s) based on the principle of synthetic lethality.