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We selected the 12 most significant SNPs based on the LD pattern (one for HGB; three each for RBC, MCV, and MCH; and two for MCHC; these 12 SNPs are independent; i.e., r < 0.3) associated with six RBC traits in the discovery cohort, and tested their association in the replication cohort.
Based on the LD pattern, we defined one haplotype block in each gene [see Supplemental Material, Figure 1A C (http://www.ehponline.org/members/2008/11117/suppl.pdf)].
Haplotype structures were generated for both the UK trios and the UK|CC cohorts using the solid spine algorithm in Haploview based on the LD between SNPs (http://www.broadinstitute.org/mpg/haploview) with confidence intervals of 0.98 and 0.70 for LD.
The in-line SFV particle size data, obtained every 10 s during processing, further allowed to explain and better understand the (in)significance of the studied DOE variables, which was not possible based on the LD data as this technique only supplied end granule size information.
It is thus inappropriate to describe the lateral location of a vehicle trajectory based on the LD.
Reconstructed counts in healthy liver tissues were unaffected, and there was a generally lower count value in lesions following CT-AC based on the LD non-enhanced images.
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While the inverse relation between power and distance can already be expected based on the LD-distance graph (Fig. 2(d)), this was also directly confirmed by evaluating the influence of increasing the distance between tagSNP and signal on power to detect this signal (Suppl. Fig. S3): when the distance increases, the power drops.
The coefficients of the LD formulation have been phenomenologically derived based on the proposed LD model.
Given that the 22 SNP considered were in LD, adjustment for multiple comparisons was performed according to Nyholt (42) based on the observed LD pattern within each population.
Based on the proposed LD potential and coefficients, the predicted results for BaTiO3 crystal have also been compared with experimental results as well as theoretically results reported by other researchers.
To determine the population structure of the collection, a 948 SNP panel based on the above LD decay results and with a mean interval distance of 390,228 pb was designed.
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