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Based on the integrated data, the genotoxic risk and the safety margin need to be assessed, including the cut-off concentration or permissible daily exposure in the female partner below which the predicted genotoxic risk is low, hence, for which highly effective contraception including condom use is not needed.
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Following XPN correction the integrated data clustered based on true biological differences with two clear clusters representing the basal/Her2 intrinsic subtype and the luminal subtype for each of the intrinsic centroids.
The Digital Factory, a virtual representation of a real factory based on an integrated data model, provides an important contribution to attain this goal.
Furthermore, in Section "Discussion" we discuss the observed trends in the field and the possibility of CAD systems based on integrated data sources.
External control incidences were calculated based on integrated data from the rituximab RA clinical development program that used pooled data of all patients exposed to rituximab (all-exposure population).
Pathway analysis based on integrated data is evidently superior due to consistency and coverage issues among databases.
Finally, in the case of brain, we demonstrate that when PEM values show good correlation, predictions of tissue-specific expression based on integrated data are very accurate.
Overall, this comprehensive PopPK analysis based on integrated data from five clinical studies provided a quantitative description of vismodegib PK with sound mechanistic hypotheses and reasonable parameter estimates.
The possibilities for new connected devices and new services based on integrating the data from those devices with open data from the cloud are endless.
We present a CONCRETE Chinese NLP Pipeline: an NLP stack built using a series of open source systems integrated based on the CONCRETE data schema.
The current DENdb implementation contains enhancers predicted by five different methods and integrates regulatory-based information based on the data from five other sources.
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