Because energy metabolism is being recognized as a/the critical pathway regulating the immortalization-to-senescence transition, metformin-based therapies based on the induction of senescence would prevent the generation of CSCs.
Therefore, we estimated the activation of mp53 based on the induction of WAF1 which is one of downstream factors regulated by p53.
The activity of AGE-preparations was confirmed using the one stage clotting assay as previously described[ 19], which is based on the induction of tissue factor on the surface of endothelial cells.
An interesting example of a vaccine against chronic diseases based on the induction of self-antigen-specific antibodies.
The method is based on the induction of the bioluminescent activity of genetically manipulated mammalian cells.
Then the nucleation mechanism was investigated based on the induction time.
Many vaccines developed against these diseases remain, similar to classical vaccines, based on the induction of antibody responses.
Furthermore, based on the induction period (ip), the antioxidant BHT was the most efficient in preventing the oxidation of the B100 biodiesel used.
Current state-of-the-art flotation modelling combines computational fluid dynamics (CFD) with user-defined algorithms based on the "induction time" concept to describe selective bubble particle attachment and separation of hydrophobic and hydrophilic particles.
Of note, OMVs can be designed to deliver their cargo in an intracellular fashion, allowing the potential induction of cellular responses instead of the more traditional approach of vaccine, which is mostly based on the induction of antibody responses.
