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These algorithms are often based on the "guilt by association" principle that suggests that interacting neighbors in protein-protein interaction (PPI) networks might also share a function [9] [11].
Based on the guilt by association principle, it is likely that Hcrt and Pmch share related functions, which are different from that of Avp.
The families assigned to M t share common co-occurrence patterns, and were therefore likely to be functionally coupled based on the "guilt by association" principle [ 39].
A system-level approach to function prediction of unknown omics molecules can be performed by constructing a network of such molecules and by analyzing the clusters in the network based on the "guilt by association" philosophy [ 1].
On the other hand, the expression data obtained from ABA images provide much greater detailed information on the three-dimensional distribution of a gene in mouse brain and hence enables us to study gene function with greater confidence based on the guilt by association principle.
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We have investigated publicly available gene expression data to predict the function of human genes based on the guilt-by-association principle.
However, all methods based on the "guilt-by-indirect-association" principle thus far are designed to be used with one or more protein-protein interaction networks.
Transcriptional coordination, or coexpression, of genes may be an indication of functional relatedness, based on the "guilt-by-association" principle [ 44].
The first group is designed based on the guilt-by-association principle, which suggests that genes associated with the same type of disease are similar in their functions [ 5].
Although approaches have been proposed either based on the guilt-by-association principle or making use of disease phenotype similarities, the low coverage of both diseases and genes in existing methods has been preventing the scan of causative genes for a significant proportion of diseases at the whole-genome level.
Its decision was not based on the presumed guilt or innocence of Knox or Sollecito, but was intended to hinge solely on whether or not the appellate trial had been properly conducted.
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based on the condemnation
based on the sin
based on the regret
based on the guilty
based on the biography
based on the leader
based on the book
based on the translation
based on the story
based on the play
based on the religion
based on the life
based on the novel
based on the spread
based on the law
based on the feedback
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Justyna Jupowicz-Kozak
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