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Based on the enrolment criteria and EA level, patients were assigned to the conventional treatment group (Group 1) or the conventional plus hemoperfusion therapy with LPS adsorber (Alteco Medical AB, Lund, Sweden) group (Group 2).
The expected mean follow-up time is 3.3 years based on the enrolment of 700 patients, and 2.8 years for the enrolment of 1000 patients according to the pre-specified interim statistical analysis.
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Patients were split into two halves based on the time of enrolment at each participating centre.
Based on the time of enrolment, the first 103 cases were assigned to the training cohort and the remaining 76 cases were assigned to the validation cohort.
Sample size was calculated based on the reported CHF enrolment rate in each district (11% in Kongwa and 27% in Mpwapwa) and a power of 80%.
We did not request owners to detail where they heard about the project to support the inferences we have made based on the time of enrolment relative to the recruitment timeline.
The daily assessment of PCT guided interventions will be as follows: A) Subjects with PCT levels > 1.00 ng/ml based on the first determination after enrolment into the study will follow the principles for interventions as detailed below.
Participants were classified as current, former or never smokers 1 year before study enrolment based on the self-reported information collected in the WABOHS.
However, trials of early treatment of infants based on oxygenation criteria or of later enrolment based on the risk of CLD did not demonstrate significant benefit of iNO for the primary end point of death or CLD at 36 weeks, when analyzed according to standard aggregate data meta-analytic techniques.
The duration of diabetes at enrolment was based on the difference between age of participants when first diagnosed with diabetes and age at enrolment.
Initially, antiretroviral therapy enrolment was based on the world health organization (WHO) clinical staging only, but CD4 and viral load testing were later introduced.
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based on the hiring
based on the utilisation
based on the insertion
based on the recordings
based on the registered
based on the textual
based on the coverage
based on the accession
based on the recruitment
based on the intake
based on the registration
based on the subscription
based on the inclusion
based on the registry
based on the addition
based on the register
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