Sentence examples for based on the downregulation from inspiring English sources

Notch pathway downregulation was confirmed based on the downregulation of HES and HEY family members.

siRNA screens, in contrast to chemical biology screens, are based on the downregulation of the abundance of a particular protein.

This modulation is based on the downregulation of cell surface molecules that participate in immune recognition, both on target and on effector cells.

Nitrogen metabolism appears to be affected in AtHb1 seeds based on the downregulation of nitrate reductase 2 (NIAt1g371307130) and nitrite reductase 1 (NiR1, At2g15620).

These findings suggest that ECs in SSc may have a diminished response to these chemokines based on the downregulation of their receptor.

We evaluated the transfection efficiency of the miRNAs in cancer cell lines based on the downregulation of mRNA expression levels of protein tyrosine kinase 9 (PTK9, alias as twinfilin: TWF1) after miR-1 transfection.

Based on the observed downregulation of lipogenic genes (e.g., ACACA, FASN; Table S1, Additional File 2) as well as serine palmitoyl transferase (SPTLC2; Additional File 2) it was apparent that ceramide synthesis was decreased, which likely explains the down-regulation of other genes that are part of its signaling pathway (Additional Files 7 and 9).

Tea is a popular beverage and the tea catechins, namely EGCG (in both green and black tea), theaflavins, and thearubigins, the black tea polyphenols, showed enough potentiality to provide neuroprotection against AD, based on the upregulation or downregulation of the signaling pathways influencing the disease pathogenesis.

Based on the incidence of RUNX3 downregulation in background gastric mucosa, it is suggested that the risk of carcinogenesis in the RB or RM groups is higher than that of the GCI group.

We conclude that the action of juvenile hormone on the intestine is direct based on the fact that 1) downregulation of the juvenile hormone receptors specifically in adult intestinal progenitors or enterocytes, and 2) activation of the pathway specifically in these cells by Kr-h1 expression both recapitulate phenotypes resulting from changes in systemic JH signalling and/or or JH analogue feeding.

In total, 1,036 genes demonstrated a significant upregulation or downregulation based on the microarray results.