Since the dispensing data do not contain information on the daily dose, we will develop an algorithm for each medicine of interest based on the amount dispensed, the number of repeats, the average time between refills by person and typical dosage, as we have carried out previously.
The Hospital Pharmacy identified warded patients from the respective services based on the prescriptions dispensed.
Compliance was documented by study personnel based on the medications dispensed and returned; patients tracked the medication use via electronic diaries.
Discrepancies between recorded days-supply and dispensed quantity were common in the PharmaNet database; hence, we also calculated days-supply based on the quantity dispensed, which, if required, was imputed using the recorded total cost.
For injected therapies, an average daily dose was calculated based on the strength, quantity dispensed, and days' supply for specified fills (strength×quantity dispensed/days supply).
Gislason et al. used personal, timely local dosages to estimate refill lengths based on the number of dispensed tablets [ 12, 13].
As a result of the success she received as the relationship expert on The Vontella Show, Liz signs a book deal based on the sketch, and begins dispensing relationship advice to the female staff of TGS, and to Angie Jordan (Sherri Shepherd and Paula Hornberger Paula Pellll), the wives of TGS star Tracy Jordan Tracy Morgann) and producer Pete Hornberger Scott Adsitt), respectively.
In addition, we adjusted the numerator to include any medication still available based on the most recent dispensing prior to randomization.
