Sentence examples for based on the blockade from inspiring English sources

Nevertheless, using a two-tissue compartment model (which showed a better goodness-of-fit than one-compartmental model), we found no evidence of specific binding based on the blockade studies.

Anti-resorptive agents, including oral or parenteral aminobisphosphonates (e.g. alendronate, risedronate, ibandronate, and zolendronate), with a mechanism of action based on the blockade of mevalonate metabolism, play an outstanding role in the management of osteoporosis.

The potential of immunotherapeutic protocols based on the blockade of antigen presentation has been underscored in RA, including targeting co-stimulatory or MHC class II molecules [ 55, 56] on APCs or T cell adhesion molecules on T cells [ 57], which has prompted the search for new ways of down-regulating antigen presentation in vivo.

Although postulated for about 20 years based on the D2 blockade effect common to all antipsychotics, it was not until the mid-1990s that PET and SPET imaging studies provided supporting evidence.

The main effect of ketamine, s-ketamine, and MK 801 is based on the noncompetitive blockade of the NMDA receptor complex.

Based on the observation that blockade of endocytosis reduced the secretion of Aβ by ∼ 70%, it was concluded that primarily endocytosed APP was cleaved (Cirrito et al., 2008).

The strategy was based on the prior knowledge that blockade of angiotensin II receptor I (AT1R) activity reduces excessive TGF-β signaling in experimental renal and cardiac fibrosis [ 94, 95].

Current treatment for diabetes remains conservative care including glycemic and blood pressure control based on the renin-angiotensin system blockade with a low-protein diet and lipid-lowering agents.

Based on the differential responses to EGFR blockade, we examined levels of EGFR protein in PRC3 and WT8 cells following treatment with Iressa or rapamycin.

The position to recommend conservative therapy in patients with secondary FSGS is based on the fact that angiotensin II blockade is usually able to reduce proteinuria to sub-nephrotic levels in these patients.

Based on the present findings, systemic calcium channel blockade may not be a useful therapeutic strategy for DMD, as it may result in an aggravation of heart pathology.