16 From the 40 samples, 19 (47%) had not been classified based on the FAB AML classification, of which eight patients had recurrent AML (8/19; 42%).
Based on the calculated AML significance level, we assigned one of the following categories (A E) to each publication: A, AML RR > 1, p < 0.1; B, AML RR > 1, 0.1 ≤ p < 0.2; C, AML RR > 1, p ≥ 0.2; D, AML RR ≤ 1; E, no AML RR reported.
We then investigated whether phenotype 1/2 or cells based on the FAB AML classification were associated with a particular phospho-protein expression pattern.
The DCOG AML 87 protocol was based on the concurrent AML-BFM protocol.
We used samples from relapsed AML patients based on the assumption that AML blasts in advanced disease will show increased phosphorylation levels.
We have previously established a robust xenotransplantation model to study primary human AML biology and stem cell function based on the engraftment of primary AML samples into non-obese diabetic (NOD)/LtSz-severe combined immunodeficiency (SCID) IL2Rγcnull (NSG) mice.
In the EDA, the individuals are encoded based on the activity-mode list (AML) and decoded by the multi-mode serial schedule generation scheme (MSSGS), and a novel probability model and an updating mechanism are proposed for well sampling the promising searching region.
In contrast, the present study is based on the Swedish national population-based AML registry with karyotypic data retrieved from cytogenetic analyses performed as part of clinical routine.
Signaling profiles were assessed in samples from two groups of Cytogenetically Normal (CN) AML patients, each representing a clinically extreme example of an "outlier" (based on the molecular characterization): 1) FLT3-WT AML who experienced disease relapse within three months after initial remission and 2) FLT3-ITD AML in complete continuous disease remission for two or more years.
Prior response for AML patients and response to transplant was determined based on the revised International Working Group criteria for AML response.
