Sentence examples for based on the aberrant from inspiring English sources
In summary, based on the aberrant miRNA expression profiles identified in human cancers, miRNAs give us a totally new horizon in understanding the development management of cancer.
Based on the aberrant expression of hK7 in pancreatic cancer, in this study we sought to determine whether the desmogleins may be substrates of hK7 in pancreatic cancer.
Based on the aberrant EMT response observed in dominant negative Src expressing NMuMG cells, we suspected that their invasion through synthetic basement membranes would also be impaired.
The first hypothesis, based on the aberrant abdominal and umbilical vascular pattern of affected individuals, postulates a primary vascular defect that leaves the caudal part of the embryo hypoperfused.
The vascular steal hypothesis is based on the aberrant vasculature pattern of the caudal body present in most individuals with sirenomelia (Kampmeier, 1927; Kallen and Winberg, 1974; Stevenson et al., 1986).
Microarray-based gene expression analysis revealed that T-ALL patients cluster into four major groups based on the aberrant, subtype-specific expression of transcriptional factors TLX1 or TLX3 (HOX family), LYL1 (HLH family), and TAL1 oncogenes [ 27].
The percentage frequency of aberrant cells was calculated based on the number of aberrant cells per total cells scored at each extract concentration.
FC-based MRD assessment is based on the detection of the aberrant phenotype of myeloma plasma cells and is therefore predominantly detecting the plasma cell component and hence will miss the clonogenic MPCs.
In addition, other groups approached a therapy based on the correction of aberrant pre-mRNA splicing [ 17, 18].
Further, urothelial tissues affected by UC could be clearly distinguished from normal urothelia based on the presence of aberrant DNA methylation regions in cancer-associated genes such as CDH1[ 21], RASSF1A[ 11] and RUNX3[ 22] with sufficient sensitivity and specificity.
Our discussion of the implications of altered miRNAs in the carcinogenic risk of RDX suggested by a previous study (Lish et al. 1984) are based on the knowledge that aberrant miRNA expression is associated with a broad range of cancers (Zhang et al. 2007).
