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Based on that prior work, limitations from previous nonrandomized quality improvement studies and promising gains in process of care measures demonstrated from previous randomized trials, we and the Cardiological Society of India Kerala chapter sought to develop, implement, and evaluate a quality improvement intervention to improve process of care measures and clinical outcomes for these patients.
In particular we must have p e f = ∫ P e f | D P e (D ) d D where p e f is the empirical prior, P e f | D the posterior based on that prior, and P e (D ) is the empirically observed distribution of the data.
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However, the prediction is based on the prior assumption that the structure-activity relationship is implicitly contained in the training set.
They examined specifically the role of TOR in aging based on the prior knowledge that both TOR and life span are regulated by nutrients and insulin.
This approach is based on the prior hypothesis that such loss-of-function mutations are more likely to cause severe phenotypic effects commonly seen in rare diseases.
The strategy was based on the prior knowledge that blockade of angiotensin II receptor I (AT1R) activity reduces excessive TGF-β signaling in experimental renal and cardiac fibrosis [ 94, 95].
To circumvent this problem, a size-filter was used to discard small segmented areas when the areas are less than a small positive threshold α based on the prior knowledge that true pigmentation is usually larger than α pixels.
The method is based on that of Prior et al. [ 21] for measuring the antioxidant capacity of plasma and other biological samples.
Migration rates and population sizes were restricted based on priors that generated generally well-behaved posterior distributions in optimizing runs (q1 1, q2 10, qA 200, m1 100, m2 5).
We use only the structure of the MP to compute semantic similarity based on prior work that has shown that MP-based similarity measures outperform measures that use HPO or the combination of HPO and MP for analyzing mouse phenotype data (Oellrich et al., 2012).
Based on prior work that estimates that 2 10 molecules of mtDNA are found in each mitochondrion [28], [29], we make the conservative estimate that more than 90% of the mitochondria in pol γ-β1/β2 and tam3/tam9 mutant backgrounds lack mtDNA.
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