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However, the CLP model has several complexities that influence outcomes: effects of age and gender; the tremendous heterogeneity of immune and inflammatory responses related to genetic strains of mice; influences of therapeutic interventions; and dramatic differences in outcomes based on technical approaches (number of cecal punctures, needle size, amount of cecum ligated; Rittirsch et al, 2009).
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The submitted manuscript provides a well written and interesting commentary on the topic and suggests two key approaches to improve reproducibility, based on technical review and incentivizing replication.
The 14 people are to be chosen based on technical expertise.
His recommendation of LMT is based on technical analysis.
Generally, the selection is based on technical and economical requirements.
And then we'd submit it back and they would have notes, based on technical things.
Our conclusion is based on multiple technical approaches.
Every year or so I update my views on technical approaches to the market.
Their validation should be based on three approaches: technical and clinical reliability, data protection and cybersecurity.
Finally, validation with qRT-PCR, a method that is based on a different technical approach, confirmed microarray hybridization data with the exception of a single gene, CDK2-associated protein 1, which showed a positive, but not significant correlation between results of the two different methodologies (Table 7).
At the request of the HLTF Working Group (Constraints to Scaling Up and Costs), two technical teams were established to provide costing estimates; one based on a normative approach and one based on a country based model using a marginal costing approach.
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