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The view presented has important implications for the development of new therapeutic strategies based on targeting specific elements of alanine-glyoxylate aminotransferase homeostasis.
This concept opens the view on novel therapeutic strategies based on targeting specific TRPC3 functions or its molecular coupling to NCX1.
The view presented has important implications for the development of new therapeutic strategies for PH1 based on targeting specific elements of AGT protein homeostasis (summarized in Figure 3).
In such contexts, the design and evaluation of prevention measures or containment policies is naturally based on targeting specific classes of individuals.
The method is based on targeting specific viral proteins which consequently leads to the shutdown of the protein expression process, thereby stopping viral replication.
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Objectives: The Tox21 partners agreed to develop a vision and devise an implementation strategy to shift the assessment of chemical hazards away from traditional experimental animal toxicology studies to one based on target-specific, mechanism-based, biological observations largely obtained using in vitro assays.
We have developed the design optimization technique for TAP PCF-LPGs employing the finite element method for PCF modal analysis in a combination with the Nelder Mead simplex method for minimizing the objective function based on target-specific PCF properties.
Microsystem based MACS technologies (μMACS) allows high-throughput sorting of target cancer cells from the clinical samples based on target-specific affinity markers [ 42, 48].
Comparison of percentage specific binders from pannings of primary libraries (expressing random peptides) vs. secondary libraries (based on target-specific primary surrogates) is shown in this Table.
Drug companies hope to develop new diagnostic tests and, in the longer term, new drugs and treatments based on targeting the specific sequences of DNA involved in disease.
This model is not based on targeting any specific signaling pathway, but on the inactivation of cell cycle regulators associated with human mammary and extra-uterine Müllerian cancer predisposition.
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