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Various prognostic and/or predictive signatures based on targeted molecular markers or gene expression profiles have been tested in CRC (Van Schaeybroeck et al, 2011).
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In the past few years, a molecular approach based on targeted gene disruption has revealed fascinating biological roles for many of the sexual stage gene products.
The HEDEP based on targeted exome capture technology is an efficient method for molecular diagnosis in adRP patients.
Case selection was based on targeted keyword searching of the 250 character narrative.
This could be achieved through tailoring feedback based on targeted individual factors.
It is therefore likely that new risk prediction models based on targeted biopsies will be required.
Initial studies on targeted molecular imaging of c-MET were therefore mainly based on HGF ligands.
Based on molecular targeted strategy, this study can facilitate the discovery of superior MDR reducing agents to provide a more effective and safer way of resensitizing MDR.
The development of targeted probes based on the molecular engineering of luminescent proteins has allowed the specific measurement of Ca2+ concentration ([Ca2+]) and adenosine trisphosphate concentration ([ATP]) in intracellular organelles or cytoplasmic subdomains.
Given the prevalence and poor prognosis of oesophageal cancer, advances in chemotherapy and targeted therapies based on key molecular pathways are greatly needed.
These preliminary results suggest that in early clinical trials, matching patients with targeted drugs based on their molecular profile results in (a) longer TTF compared to their prior therapy and (b) higher rates of response, survival and TTF compared to those seen in patients treated without molecular matching.
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