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"Information technology now is based on such small objects you just can't use conventional superconductors," notes Robinson.
These percentage agreement and kappa coefficients based on such small numbers should be interpreted with caution.
Consequently, authors often noted that they were wary of drawing definitive conclusions based on such small sample sizes.
Since a disease generally only associates with a few disease genes, it is hard to perform a logistic regression based on such small amount of positive samples.
The results of these items are not shown, because percentage agreement and kappa coefficients based on such small numbers are unreliable.
18 Some of these variables (eg, age, income, education and gender) have been consistently found to be associated with risk of harmful drinking and alcohol abuse i in old age across the literature at least since the late 1980s, 22 although some studies are based on such small samples 23 that low statistical power may have affected the SEs and, consequently, the significance of the results.
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That doesn't change the fact that Trump appears to be significantly ahead of Cruz nationally (although the margin could be much narrower at 36-24), but it does show the fragility of polling numbers that are based on such a small number of US voters.
This is known as second impact syndrome, but it is based on such a small number of cases that the diagnosis is controversial.
However, Ashley Alexander, director of estate agent review website MeetMyAgent.co.uk, said: "House price indices are based on such a small number of sales at the moment that it is difficult to say with any degree of confidence that they provide a realistic measure of market conditions".
Holmen said it's hard to draw any conclusions about how female chief executives are paid based on such a small group – but he expects that group to grow.
The total injury rates for the Canadian Taekwondo athletes compare favourably to those reported in the literature, which is contrary to what was expected based on such a small sample size.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com