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This matrix matrix multiplication is also applied in further evolutionary models based on substitution matrices.
Likewise, this step is important to all other evolutionary models based on substitution matrices.
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A distinction can be made between pairwise correlation methods (which might be based on substitution matrix scores or related physicochemical characteristics) [ 7, 8] and information-theory based methods [ 9- 11].
However, our analysis, based on substitution scores and amino acid property matrices, showed that the severity of cancer somatic mutations lies between that of Mendelian disease-related variants and polymorphic variants; less deleterious than Mendelian disease causing variants but more severe than polymorphic variants.
LG4X is a mixture model based on four substitution matrices [ 55].
LG4X is a mixture model based on four substitution matrices [ 39], whereas gcpREV is an empirical model derived from green plant chloroplast sequences [ 40].
In this novel matrix representation for proteins, a N × 20 matrix would be generated to represent a given N-length protein sequence based on a substitution matrix.
Regular scoring schemes are based on a substitution matrix, used to reward identities and penalize mismatches.
Based on particular substitutional matrix and interactively modified substitution probability "cutoff" value, amino acid residues are sorted as "rare" or "frequent".
The main improvements come from adopting a novel protein sequence representation by using discrete cosine transform (DCT) on substitution matrix representation (SMR) and from using weighted sparse representation based classifier (WSRC).
Unlike the above two models that only use crude classifications of residues, atomic types or surface properties, Binkowski et al. (Binkowski et al., 2003) and Laskowski et al. (Laskowski et al., 2005) assess the significance of the similarity by quantitatively measuring the ligand binding-site sequence aligand binding-sitemino-acid sequencetion malignment
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