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Based on subgroup interaction analyses, symptom duration, age and baseline CRP status showed significant interactions with treatment on ASAS40 response (p=0.02, p=0.05 and p=0.03, respectively; NRI).
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There was no statistically significant treatment-by-subgroup interaction observed based on subgroups defined by baseline protein C deficiency status (P = 0.3338).
In addition, explorative subgroup analyses will be performed, based on the interaction between the randomization variable and various different baseline variables (table 3).
Subgroup analyses were based on tests for interaction.
Based on factor subgroup analysis (Class room behaviour/Instructional delivery, Interaction with students/colleagues, Personal qualities and Professional development), faculty with longer teaching experience ranked 'Class room behaviour/Instruction delivery' higher than their less experienced counterparts.
Each pair of parent child subgroups is given a related factor based on their subgroup keys.
Based on a significant interaction previously found in the meta-analysis by Parienti et al [ 12], subgroup analyses were prespecified to explore the reasons for heterogeneity.
To investigate subgroup effects, the treatment effects will also be estimated within strata based on single subgrouping variables, as well as using an interaction term in the regression model.
Prediction Based on Hybrid Interactions.
Subgroup analyses were defined, a priori, based on PROWESS subgroups [ 15, 16].
We also performed analysis based on age subgroups, but no linkage to chromosome 9 was detected in either subgroup.
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