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The second mechanism is based on subcellular localization (Fig. 8b, bottom).
In addition to looking for COG enrichment, we also analyzed enrichment based on subcellular localization of proteins.
It was converted to a layered network based on subcellular localization information.
Here, we delineate possible functional roles based on subcellular localization for SUMO-1 and SUMO-2/3.
The analysed largest connected component of this PPI network was divided in four layers, based on subcellular localization information.
MKPs are classified into three subgroups based on subcellular localization, tissue distribution and substrate preference [ 44, 45].
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The relative abundance of the 25 most abundant proteins identified is provided in Additional file 4. GO-based annotation was used to categorize the proteins based on their subcellular localization, molecular function and biological processes.
Importantly, these methods allow us to detect potential posttranslational modification of the mKIAA/KIAA proteins and to predict their biological function based on their subcellular localization.
Based on the subcellular localization, non-GPI-anchor modification, and transmembrane predictions, we postulated that OsRUS proteins highly possible localize to the chloroplast membrane.
HSF/HSP responses are recognized as central chaperone components against unfolded protein accumulation, a signal for triggering HSR, UPR, or CPR based on distinct subcellular localization (Aparicio et al. 2005; Swindell et al. 2007; Yeh et al. 2007).
After a brief historical review about the increasing knowledge on myelin and my elin disorders, we propose a new classification of myelin disorders based on the subcellular localization of the enzymatic defects as far as the inborn errors of me tabolism are concerned.
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based on actual localization
based on anatomical localization
based on cellular localization
based on precise localization
based on subcellular localisation
based on immunofluorescent localization
based on ocular localization
based on subcellular fractionation
based on normal localization
based on oral localization
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