On each working day, up to 10 voluntary blood donors were enrolled in the study after obtaining written informed consent and passing screening based on study inclusion and exclusion criteria.
Compared to fax, call attempts from all other recruitment methods were statistically significantly different (p < 0.001).> We have recruitment data on 4123 individuals (3169 eligible referrals, 954 ineligible referrals based on study inclusion and exclusion criteria).
Lastly, we did not make any study exclusions based on study quality, but did conduct a restricted secondary analysis excluding studies with a poor overall quality score and used the results of this analysis to form our conclusions.
No exclusions were made based on study type; thus, systematic reviews and primary studies without a control group (e.g., feasibility studies) were also included.
1252 patients were excluded based on study inclusion/exclusion criteria; finally 130 patients were included (fluconazole, n = 65; posaconazole, n = 65; Fig. 1).
The judgment of clinical homogeneity was based on study design, risk of bias, inclusion/exclusion criteria, baseline participant characteristics and treatment regimen.
Following removal of duplicate reports, a first decision on inclusion/exclusion was made based on study titles and abstracts.
Further defining the endemic and non-endemic areas with specific exclusion criteria based on study-specific quantitative laboratory and survey data is also preferable in future studies [ 10, 22].
The model of care chosen for methadone induction in primary care was based on study-specific pre-training of all physicians, exclusion criteria and daily supervision of methadone during the initiation phase.
