Most toxicity data are based on studies using single compounds.
Dr. Swan's 1987 report and related news articles brought the matter back into the spotlight, challenging Dr. McBride's research, which was based on studies using rabbits.
Although most studies so far indicate that antagonists for SUCNR1 might be optimal from a therapeutic perspective this has yet to be experimentally confirmed and is mainly based on studies using the natural agonist succinate, a compound that beside its relatively weak potency also is an intermediate in the citric acid cycle and exerts effects unrelated to SUCNR1.
While a variety of risk factors for substance abuse have been identified, the psychological mechanisms underlying the transmission of risk is unclear based on studies using traditional risk-outcome research designs.
Based on studies using 70 strains of L. lactis and 60 strains of other non-target bacteria, the identification completely matched that obtained by the sequence of the 16S rRNA gene.
The design of this novel challenge plasmid was based on studies using luciferase and SEAP as reporter molecules to examine the kinetics of the proteins expressed in hepatocytes and secreted into blood.
Based on studies using modern neuroimaging, the presence of acute facial paresis, arm drift, or abnormal speech increases the likelihood of stroke (LR of > or =1 finding = 5.5; 95% CI, 3.3-9.1), while the absence of all 3 decreases the odds (LR of 0 findings = 0.39; 95% CI, 0.25-0.61).
Of note, the cut-off values of LI used here were based on our previous study in RCVS patients using TCCS[7] and should not be translated to the same severity of vasopasm in SAH based on studies using transcranial Doppler (TCD)[22].
However, the OA cell volume was somewhat larger than the cell volume of the AC precipitate (Table 4 --a finding that is contrary to what van der Houwen et al. (2003) reported based on studies using a higher concentration of organic acids (1 mM) in solution.
Based on studies using morphology, immunology, repetitive DNA, SINE analysis, multilocus phylogenetic tests, and mitochondrial genes (mtDNA), giant mouse lemurs are most closely related to mouse lemurs within family Cheirogaleidae, and together they form a clade with the hairy-eared dwarf lemur (Allocebus).
Thus, conclusions based on studies using concentrations in the micromolar range may be subject to misinterpretation.
