Sentence examples for based on structure modifications from inspiring English sources

These compounds were designed to maximize inhibition of P-glycoprotein and minimize calcium channel binding activity, based on structure modifications of niguldipine.

This piece is based on structure, not note by note.

Based on its structure and through further structure modification, compound 25, which exhibited the most potent inhibitory activity with an IC50 value of 0.16 μM for BRAFV600E and GI50 value of 0.24 μM for mutant BRAF-dependent melanoma cells, was obtained.

Based on the protein structures, modifications of the inhibitors can be proposed which have led to selective inhibitors and to compounds inhibiting the resistant variant of the target protein.

The effect of anthracyclines on cancer cells is also based on the modification of DNA structure by reactive oxygen species.

These novel inhibitors were designed based on the structure of Darunavir with modification on the P2 and P2′ position.

They are mainly based on the modification of the PG structure (pgdA and oatA for S. pneumoniae [14], [38]) associated to the reduction of the cell surface net charge (oatA and dltA for S. aureus [13], [15], or pgdA, oatA and dlt for L. lactis [39], [40]).

Next, various MQCM schemes to minimize interference and enhance sensitivity of conventional MQCM devices based on modification of quartz substrate structure are digested.

These limits were based on modifications of criteria for rotation capacity commonly used for steel structures.

In this paper we propose new structures of fractal photonic crystal fiber (F-PCF) based on modifications of second and third order Sierpinski fractal.

To investigate the effect of CH3NH3I modification on the performance of PSCs, the devices based on the structure illustrated in Fig. 1 are fabricated.