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At the same time, the importance of GPCR modeling studies that are not based on structural templates comes from the fact that out of >1000 known GPCRs, only one such potential template exists (rhodopsin).
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The models were calculated with RAMPAGE [ 30] and ProSA-web [ 31] based on structural comparison with template.
After slice-timing correction of the images, SPM2 [36]was used for image realignment, smoothing with a 3-D 9 mm isotropic Gaussian kernel, and normalization into the Montreal Neurological Institute averaged template based on structural MRIs from 152 brains.
The Vfold model predicts the 3D structure for a 2D structure based on the structural templates.
Each participant's 3D structural image (coregistered to the functional data) was transformed, via a 12-parameter affine transformation, to fit it to a Talairach template (i.e., the Colin-brain template), and then the t-value matrix was transformed to Talairach space based on structural image transformation parameters.
The SVM is based on structural risk minimization theory [46].
SVM algorithms are based on structural risk minimization.
While Incremental SVM is based on structural risk minimization.
(B ) Cross-linking strategy based on structural models.
We have designed and synthesized several series of donors based on different structural templates.
The major enzymes of the methanogenic pathway and some common enzymes involved in co-factor biosynthesis are listed in Additional File 3. We modeled two subunits FwdB (UniProt AC: P61154) and FwdD (UniProt AC: Q58568) from M. jannashii based on two structural templates: formate dehydrogenase H (FdhH) from E.coli (PDB ID: 1fdo chain A) and FwdD from Archaeoglobus fulgidus (PDB ID: 2ki8 chain A).
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