For this approach, we employ detailed structure comparisons, and based on structural similarities, we choose the fragments used for recombination.
Since theaflavins in BTE are composed of a dimer structure formed from catechin monomers found in green tea, which have been found to inhibit HSV-1 [ 15], it is reasonable to infer that theaflavins in BTE may also produce similar results based on structural similarities.
The SCOP, CATH and DALI databases classify protein structures into a hierarchy based on structural similarities (Murzin et al., 1995).
According to the predominant cognitive models, analogical reasoning includes 1) generation of structured mental representations and 2) mapping based on structural similarities between them.
Based on structural similarities, we hypothesized that hybrid molecules of belactosin C, a known proteasome inhibitor, and orlistat, a known inhibitor of the thioesterase domain of FAS, could inhibit both enzymes.
Proximate explanations cite species concepts based on structural similarities, such as genetic, chromosomal and developmental similarities.
The expectation may have a format of S-representation in Cummins's (1996) sense, which means it is a model based on structural similarity relationships, and one can decide the format of the representation by inquiring the way the expectation is evaluated in the animal.
In case a database does not contain the sample compound an obvious approach is to search for similar spectra, assuming that spectral similarity is based on structural similarity of the compounds.
A PPi-dependent kinase belonging to the ribokinase family was identified based on structural similarity to a myo-inositol 3-kinase from the hyperthermophilic archaeon Thermococcus kodakarensis (MI3K_TK), which is an ATP-dependent member of the ribokinase family19,20.
