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In this study, we have achieved a new type of STAT3 inhibitors based on structural modifications on shikonin scaffold, guided by computational modelling.
This article introduces a new method for generating benchmarks that is based on structural modifications of a user-specified design without altering its function.
In this review we describe our work on the rational design and development of new soluble, thermally stable, and highly reactive hypervalent iodine reagents based on structural modifications that lead to redirection of secondary bonding from intermolecular to intramolecular modes.
The Halteria concept also contradicts traditional interpretations of morphological characters uniting Strepsiptera and Coleoptera based on structural modifications due to posteromotorism or hindwing-powered flight [ 7].
RESULTS: This study developed a novel, non-toxic and potent immunosuppressive regulatory ODN after screening of a set of new ODNs, based on structural modifications of existing ODNs.
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Starting from this new scaffold, SAR exploration was investigated based on structural modification on A-ring, C-ring and D-ring.
We also propose two potential mechanisms for EF-P modification, based on structural and functional characteristics of the YjeA and YjeK families of enzymes.
The SVM is based on structural risk minimization theory [46].
SVM algorithms are based on structural risk minimization.
While Incremental SVM is based on structural risk minimization.
The optimization principle is based on structural risk minimization (SRM).
More suggestions(16)
based on configurational modifications
based on triple modifications
based on posttranslational modifications
based on structural arguments
based on structural abnormalities
based on different modifications
based on structural sensors
based on direct modifications
based on structural trends
based on slight modifications
based on syntactic modifications
based on structural properties
based on genetic modifications
based on morphological modifications
based on simple modifications
based on structural comparisons
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