Sentence examples for based on structural alerts from inspiring English sources
Screening for potential endocrine activities in fish via estrogenic and androgenic modes of action based on structural alerts provides similar information as in vitro receptor-mediated assays.
The screening for potential EA-EDs based on structural alerts relative to in vitro classifications and in vivo mammalian long-term reproductive toxicities is shown in Table 7.
Besides, even though those studies give a comprehensive understanding of the phenomenon, they do not provide substructural information that could be useful forward improving expert systems based on structural alerts (SAs).
The results of this study have been used to develop a computerized screening tool for the German Environment Agency (Umweltbundesamt, UBA) to identify potential EA-EDs with regard to the environment based on structural alerts related to binding to estrogen and androgen receptors.
"All this falls under the big umbrella of targeted drug design based on structural biology," Dr. Fauci said.
The CAESAR tool is based on the structural alerts described by Ashby, Kazius et al. [36].
Other than that the comparative results of descriptor based Random Forest with CAESAR (which is based on the structural alerts) clearly shows that Random Forest has the better predictive ability to classify mutagenic from non-mutagenic.
To achieve a tool more suitable for regulatory purposes, a mutagenicity classifier has been arranged integrating two different techniques: a machine learning algorithm from the Support Vector Machines (SVM) collection, to build an early model with the best statistical accuracy, then an ad hoc expert system based on known structural alerts (SAs), tailored to refine its predictions.
Expert systems have shown success in predicting toxic risk by applying established knowledge of toxicology encoded as a knowledge base of structural alerts and a reasoning model.
Screening for potential endocrine disruptors in fish was approached based on evidence from structural alerts and in vitro and in vivo toxicological assays.
Alert override rate and adherence rate were calculated based on total alerts.
