The first condition ensures that target prediction be consistent with ES-up/-down feature definitions, which are based on statistical significance of one-sided test results; the operation in the second condition intends to mimic knockout of a TF combination and to check expected expression change of potential targets.
However, reliance on a vote-counting approach based on statistical significance can be extremely misleading since the absence of a statistically significant effect does not mean that an effect is absent [ 34].
Decisions about conclusiveness and dissemination of research findings are commonly based on statistical significance (only) and this practice is likely to affect any network of evidence.
Using this design, smaller number of patients are required compared to the usual randomised trial design in which sample size calculations are based on statistical significance.
Once a final model was obtained, those variables that had not met the inclusion criteria based on statistical significance were entered into the final model one at a time to see if they would contribute significantly to the model.
Model II was performed based on statistical significance (p < 0.20) of model I and represented the adjusted covariables, with predictive value significant when p ≤ 0.05.
This study was undertaken to follow up findings from a pGWAS we previously conducted in the Norfolk Island pedigree which implicated four SNPs in the RNA editing gene ADARB2 in migraine, based on statistical significance [11].
Unfortunately, many recent studies have been expressed as relative risk (RR) or odds ratios (OR) based on statistical significance that produces misleading constructs, especially when the relationship between the biomarker and disease is weak.
Using EasyGene [99], a program that ranks prokaryotic predicted ORFs based on statistical significance, Nielsen and Krogh [100] determined that the R. conorii str.
The top five networks (ranked based on statistical significance), and their associated proteins are shown in Table 1 and 2 for GV oocyte and cumulus cell, respectively.
"Gene hits" were identified for further evaluation based on statistical significance of knockdown effect (p-value<0.01 in at least 2 siRNAs per gene) plus relevant biological criterion such as percent difference above certain threshold (>25% in at least 2 siRNAs per gene).
