The parameter estimates for a conditional distribution such as μ̂ y| xi and σ̂ y|x can be calculated based on standard bivariate normal theory and the invariance property of MLE.
BMI exposure groups were based on standard clinical definitions: normal-weight BMI (18.5 24.9 kg/m), overweight (25.0 29.9 kg/m), and obese (≥30.0 kg/m).
Weight status groups were based on standard clinical definitions for BMI (normal weight 18.5 24.9 kg/m, overweight 25.0 29.9 kg/m, obese 30.0 kg/m or higher); percentage body fat (normal <30%; obese ≥30%) and waist circumference (normal ≤80.0 cm; abdominal obesity >80 cm).
The IQR model, measured outward from the median, is based on standard deviations derived from a normal Gaussian distribution [27].
Individuals were determined to be phenotypically normal based on standard history, physical exam, complete blood count, coagulation studies, liver function tests, urine studies, chest X-ray, EKG, and pulmonary function tests.
Quantification was based on standard curves from a serial dilution of human normal genomic DNA.
Quantification of four different target genes (MAP3K7, PPP3CC; SGCZ and CSMD1) was based on standard curves constructed from four-fold serially diluted normal genomic DNA samples.
The pH, Whiff test, and Pap smear tests were conducted for normal and abnormal cervical swabs based on standard protocols.
Tumor and adjacent normal mucosa tissues were surgically resected based on standard oncological procedures.
