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Each radiologist reported the post mortem MR independently on to a large Microsoft access database (Microsoft Inc, Redmond, USA), with predefined drop down menus of categorical variables and codes (based on standard autopsy reporting).
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This surveillance model, called Med-X, is based on standards for autopsy performance, diagnostic testing, and public health reporting and is currently being performed locally in a small number of offices.
The verbal autopsy tools were locally adapted and pretested based on standard instruments developed by the World Health Organization (WHO).
Patients in our series who were found at autopsy to have PNET were diagnosed as DIPG based on standard criteria including MRI and clinical presentation.
After autopsy, the brains were washed in ice-cold saline and dissected into different regions based on standard anatomical markings.
Hit selection was based on "standard scores".
Bacteria identification was based on standard methods.
Verbal autopsy is based on lay recall of events.
We used a series of structured questions to assign cause of death among under 5s into one of eight categories based on a standard verbal autopsy.
Classification of cause of death based on autopsy remains the gold standard: clinical classifications may not correlate well with classifications from autopsy reports [ 20, 21].
Various studies have previously assessed the accuracy of the clinical diagnosis of AD based on autopsy results, or the "gold standard".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com