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A library of >100 compounds was collected according to IPA, DrugBank, and Matador (Table S7), based on specific target genes or pathways/key signaling molecules suggested by Ingenuity pathway analysis.
The limitation of this approach is that the algorithm development is based on specific target conditions each of which would have their own particular clinical presentations.
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Preclinical studies based on specific targeting of viral antigens expressed in these malignancies have provided very encouraging results and thus are likely to serve as an important platform for the treatment of human patients.
We discuss the pros and cons of designing ecological indicators of abiotic stress based on specific species, targeted to specific ecological level, and needs of considering the frequency and magnitude of fresh water inflow in an estuary.
We therefore hypothesized that ANT2 can be a promising candidate for cancer therapy based on specific molecular targeting.
The AQUA strategy is based on specific detection of target proteins enabled by internal standard peptides, chosen within the target protein, and produced with a heavy isotope amino acid incorporated [ 58].
Gupta has recently left General Catalyst to found a new e-commerce company, NatureBox, which aims to provide healthy snacks to people based on specific ingredients and targeted toward specific demographics.
This is fundamental information that should be applicable to new promising strategies for cancer treatment based on specific sphingolipid metabolism targeting [ 25] either after photon or carbon ion exposure.
Mechanistic studies will clearly be important to understand the contribution of these mutations and expression changes to leukemogenesis and possibly to allow for the development of personalized therapies based on specific SNF2 or CRC targets.
It is therefore imperative that programme planners and policy makers move away from a system of circumstantial categorization and instead develop responses for young people that target based on specific, easily identified, and acute needs.
Programmes that target based on specific and well-identified needs, such as the need for education, livelihood development, and support for victims of sexual violence, are likely to be more effective than programmes that target based on abduction status; to be more oriented to self-selection, and; to be less stigmatizing.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com