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Such approaches might also be utilized for other therapeutic modalities that are based on specific gene transcription e.g. Gene dependent enzyme pro-drug therapy (GDEPT).
Their role in Alzheimer's disease is being studied and explored in order to develop a new therapeutic strategy based on specific gene silencing.
This observation revealed that GCI scores, which are based on specific gene attributes, referred to unambiguous cellular functions such as binding, receptor, transporter or enzyme activities rather than higher-ranking biological processes or cellular components of a gene's activity.
Additional file 5: Single nucleotide polymorphism phylogeny based on specific gene sets.
Biologists are increasingly interested in building conditional combinatorial gene regulatory networks based on specific gene expression data, and a web server allowing users to model conditional combinatorial gene regulatory networks from their own gene expression datasets is so valuable.
Four pairs of primers based on specific gene sequences of Wisconsin 54-1255 (Additional file 1: Table S8) were used to amplify specific genes by PCR (primers used were listed in Additional file 1: Table S8).
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Filtering based on specific genes may be useful for identifying candidate SNPs within genes already known to be related to the phenotype under study, or to identify SNPs potentially affecting a gene that other candidate SNPs fall within.
This study was designed as a confirmatory analysis based on specific genes that were previously shown to have significant expression changes in steosarcoma, and thus multiple test correction was not applicable [ 36].
We consider all H37Rv STRING PPIs as well as STRING H37Rv PPIs based on specific methods (gene neighbourhood, gene fusion, etc.; details are listed in Table 1) used for predicting them.
This seems to lead one in a different direction than much of the current PD research based on specific single gene mutations.
However, this is the first analysis that attempts to define the actual risk of desmoid tumors based on specific APC gene mutations while adjusting for the frequency distribution of APC mutations in an FAP reference population, in an attempt to obviate bias toward more common mutations.
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