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The full texts of both of these articles underwent critical appraisal [39, 40], and the studies resulted of good quality, even if based on small populations (40 enrolled in Muren et al.'s study and 53 in Nau et al.'s study).
Many of these reports, however, have been based on small populations and have used different forms of statistical analysis.
These studies generated inconsistent findings, were based on small populations, and focussed on short-term post-cholecystectomy outcomes (<5 days post-operatively) only.
While many previous studies have been based on small populations or aggregated data we have, for our purpose, access to a rich anonymized micro dataset, the so-called Linnaeus Database (25), containing, for instance, information from various administrative registers provided by Statistics Sweden as well as by the Swedish National Board of Health and Welfare.
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Thus smoothed SIR estimates are to some extent averaged over neighbouring values; this also helps address the problem of unstable empirical estimates that are based on small population sizes [ 15].
Data based on a larger base population size have more stable averages than data based on smaller populations.
The ratio of NDS mortality to cancer incidence may be more valid for the prediction equation since we used the equation to predict national incidence from national mortality, but we also expected the ratios to be less precise since they were based on smaller populations.
"All the planning assumptions are based on smaller population projections".
The 3 studies, however, were all based on small study populations and did not control for potential confounders.
However, the literature on MR imaging findings in the differentiation of these two tumours is based on small patient populations [ 12].
A number of other studies have used twin data to address the social patterning of health and disease, but the majority are based on small twin populations, focusing on continuous outcomes, such as self-rated health, body mass index, or physical activity (10– 10).
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