In our analysis, we found that the elastic net regressions based on single drug responses were not successful, while drug pair data provided statistically significant predictions.
The convolved traces (see point (i) under 'Decoding based on single neuron spike responses and principal component analysis') were also used to investigate whether the responses could be segregated using unlabeled methods that had only access to the responses but not the stimulation pattern that evoked the response.
Furthermore, theoretical studies have demonstrated that coding strategies based on the responses of a population of neurons encode more information than coding strategies based on single-cell responses (Zohary et al., 1994; Abbott and Dayan, 1999; Pouget et al., 2000; Sompolinsky et al., 2001).
Having established the primary driver of cell response at the individual cell level, this information can be used to construct a complete model of cell-nanoparticle interaction with an ab initio description of the population response based on single cell studies.
We were able to make isochrones for the onset of responses based on single sweep optical recordings.
As our analyses are based on single trials, the effect on questionnaire response of using offers of charity donations, sending reminders to trial sites and when a questionnaire is sent, may need further evaluation.
We were also interested to see whether any differences between the stimuli could be discerned from the single-trial evoked response, as based on single neuron recordings in the primate, orientation selectivity seems to be developed within the first 150 ms [Celebrini et al., 1993; Muller et al., 2001].
A response surface methodology (RSM) was used to optimize the parameters on UAE based on single factor experiment.
This time response was measured using the same method as that used for the photodetector based on single CdTe NWs.
