Sentence examples similar to based on single perturbations from inspiring English sources

These classical knockout studies are however based on single-perturbations: In each experiment, a single element in the system is perturbed, and the resulting phenotype is used to identify its function.

For example, redundancy in the network would lead to under-prediction of regulatory edges based on single gene perturbation experiments, which are the primary source of data for the GSN.

Moreover, literature data validated several predictions based on single-node perturbations that corresponded to deletion or overexpression.

All values are based on single analyses.

However, we have shown how even a fairly simple model, model (2), is capable of suggesting general hypotheses about the nature of systemwide interactions based on a single perturbation event.

An important feature of our approach is that the predictions are not based on perturbations to a single parameter set, but represent trends in the behavior of the hypotheses when all the parameter sets that generate results consistent with experimental data are considered.

Our study represents an initial attempt to integrate these disparate approaches into a single methodology based on biological gene perturbations combined with constraints from spatial modeling.

BCCs therefore provide an excellent in vivo example of cellular reprogramming based on the perturbation of a single pathway.

Based on small perturbations in the orbit of Uranus, John Adams and Urbain Le Verrier predicted the position of another, more distant planet.

Modeling provides the ability to infer functions and make predictions based on network perturbations [ 1- 6].

Robustness is estimated based on 50 perturbations (i.e. parameters), or less in case of fast convergence.