Sentence examples for based on single markers from inspiring English sources
Conventional GWAS approaches, based on single markers, require of large cohorts, typically unavailable in rare diseases.
PAMs' information (except that of the ILG motif) was used to design bipartite networks models capturing network relationships based on single markers under two different scenarios.
Remarkably, one SNP locus (CaSNP8: G/A) in the coding region of constitutive photomorphogenic9 (COP9) signalosome complex subunit 8 (CSN8) gene showing tight linkage with a major SW robust QTL (CaqSW1.1) (based on single marker analysis of traditional QTL mapping) was considered as one of the potential candidate regulating seed weight in chickpea.
Those results were based on single marker-trait associations in a genome-scan to identify broad chromosomal regions potentially containing genes affecting traits of interest.
Marker RM1089 was associated with number of tillers and yield per plant, RM423 with leaf senescence, RM584 with leaf width and RM229 with yield per plant, based on single marker analysis of F2 mapping population from the cross between IR64 and NH219.
It has been shown that a model including both haplotypes based on multiple markers and relationships between them, yields ~25 to 500 times as many effects that need to be estimated as a model based on single marker alleles [ 3].
The GeneChip Human Mapping 500K Array Set (Affymetrix, Inc., Santa Clara, CA, USA) used in the DGI GWAS has coverage in the CEU HapMap population (r≤0.8) of 67%, based on single marker test.
The test of association between a marker and QTL and the power of the test were calculated based on single-marker regression analysis.
Our previous classification of SERMs in these two cell lines was based on one single marker of E2-responsiveness in these breast cancer cells: E2 and 4OHT produced oestrogenic effects on the activation of TGFα mRNA in cell expressing wtERα whereas Ral and ICI were anti-oestrogens (Levenson et al, 1998b).
