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Early studies identified aberrant DNA methylation, often based on single gene promoter analysis with both biological and clinical impact.
Mitochondrial localization is determined by a reference set, based on single gene studies, available at the MitoP2 database (http://www.mitop.de).
These data are based on single gene analysis.
Our multilocus analyses provide inferences of gibbon evolutionary histories complementary to those based on single gene data.
In addition, strains were placed into a variety of subsets based on single gene arrangements or combinations of two gene arrangements.
This in turn can lead to erroneous inference of extensive gene flow in autosomal genes if it is based on single gene trees.
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For instance, ecomorphological convergence may confound morphology-based phylogenetic inferences, and previous molecular phylogenetic studies based on single genes have often yielded contradictory and poorly supported trees.
Gene expression is inherently noisy and random noise is expected to reduce the performance of predictors based on single genes.
By comparison, big pharma goes straight into blind testing on drugs based on single genes, usually spending around $2 billion and 12 years to get a single new drug to market.
Furthermore, inferences based on single genes could lead to erroneous conclusions and population genetic outcomes, thus usage of multiple loci is suggested.
During an initial stage phylogenetic analyses of sequence data were generally based on single genes or parts of genes [2] [4].
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