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It can be used to prioritize genes based on single data sources or a combination of different sources.
Direct concatenation generally produces worse clustering and classification results than those based on single data (Fig. 2b and c and Table 1).
The similarity scores were measured by the Pearson correlation coefficients based on single data types (DNA methylation, mRNA expression and miRNA expression) and the integrated scores (integrated by direct concatenation, SNF and iBFE).
Some performance based on single data sources were higher than those based WinDTome with Score_S ≥ 2 or Score_S ≥ 1; however, none of them is higher than those of using WinDTome with Score_S ≥ 3. It implies that the scoring system we used is promising in conducting network pharmacology studies, and the recommending cutoff of Score_S is reasonable.
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Models based on multiple omics layers outperformed the models that were based on one single data set.
Also, except for the polypharmacy deficit, this FI was based on one single data source out of the Electronic Medical Records (EMRs), namely symptoms and diagnoses encoded according to the International Classification of Primary Care ICPCC, [ 62]).
We define the intra-relation as a graph constructed based on single genomic data alone such as gene expression data.
Note that Stata does not compute goodness-of-fit measures after estimation based on multiply imputed data, which is why I use R2 (OLS) and Pseudo-R2 (Logit) from estimates based on single imputed data.
Among these platforms, personal computers, microprocessors, and DSPs are based on single instruction single data (SISD) structures.
That allows to model biogas potentials of mixtures based on single substrate data.
Our multilocus analyses provide inferences of gibbon evolutionary histories complementary to those based on single gene data.
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