Sentence examples for based on single agent from inspiring English sources
For example, Chen et al. [21] proposed a source-grouping scheme and an iterative MIP algorithm based on single agent itinerary planning in order to solve the problem of single agent itinerary planning.
Despite manageable toxicity, the ORR and 6 mo PFS did not surpass assumptions based on single agent BEV in HCC.
The rationale for combining topotecan and vinorelbine for recurrent lung cancer is primarily based on single agent activity and different toxicity profiles.
Based on single agent data, colorectal cancer and non-small-cell lung cancer should be the focus for future irinotecan studies.
Drug combinations that acted synergistically can be identified as those that exhibited significant dose reduction values (i.e. a given measured effect will be observed at dose(s) significantly lower than expected based on single agent activities).
More importantly, Tomatis realized that "exposure levels that could seem as sufficiently low when based on single agents may actually not be safe in the context of the many other concomitant carcinogenic and mutagenic exposures" [ 8] and "health effects at environmental exposure levels, especially during critical stages of development, have not been fully characterized.
The combined tolerated dose was lower than expected based on single-agent experiences.
Based on Single-agent activity, noncross-reactivity, and potential synergy, SWOG tested docetaxel/vinorelbine as first-line chemotherapy in metastatic breast cancer.
By reducing drug development costs and by speeding access to effective new therapies, approval of agents based on single-agent phase II data could reduce the costs of marketed agents, greatly increase the number of agents that can be tested using available resources, and improve patient outcomes [ 4].
