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Survival with inoperable lung cancer: an integration of prognostic variables based on simple clinical criteria.
With the goal of optimizing early management of critically ill patients, we describe in this article an algorithm based on simple clinical questions that combines the information provided by lung, cardiac and inferior vena cava ultrasonography.
Diagnostic algorithms based on simple clinical and laboratory features can be sensitive and specific [7] but require further evaluation, particularly in HIV-infected patients and children.
The algorithm is based on simple clinical variables that can be ascertained in clinical practice.
The algorithm is based on simple clinical variables which the patient is likely to know or which are routinely recorded in general practice records.
Thus, prognostic factors derived at the bedside and based on simple clinical or biochemical criteria are likely to be more widely adopted and used.
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Therefore, it is rather unlikely that a model based on simple, reliable clinical factors alone would ever have sufficient discriminatory power to limit the target population for screening.
Several biomarkers based on simple biochemical and clinical data have been developed to predict NAFLD, such as the fatty-liver index (BMI, waist, triacylglycerols [TGs], γ-glutamyltransferase) and the commercially available Steatotest (12 variables in an undisclosed formula) (reviewed in Machado and Cortez-Pinto [ 9]).
Clinical trials based on simple designs and on more comprehensive outcome measures will probably contribute to reduce the gap between research findings and clinical practice.
For instance, natural clusters were identified based on distance measure (Yule's Q); the specific groupings in 'multiple morbidity' and prevalent pairs were based on simple probability of association and the clinical clusters were based on 'concordant comorbidity'.
A great advantage of MEWS is that it is based on simple measures that are routinely collected as part of most clinical consultations.
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