Sentence examples for based on siRNA design from inspiring English sources

One is to chemically synthesize oligonucleotides based on siRNA design algorithms (for reviews, see [ 1, 2]).

This screen, while based on siRNA biochemistry, was not designed to identify targets that are degraded through siRNA-mediated slicing activity but to identify toxicity caused by moderately targeting hundreds of genes required for cell survival in a mechanism similar to miRNA-induced silencing.

Contrastly, one study did claim viral clearance based on siRNA targeting [15].

The shRNA sequences directed against human kinases were based on siRNA sequences selected using public servers such as the Whitehead siRNA selection program [ 31], the Sfold siRNA design methodology program [ 32], the GenScript siRNA Target Finder, and the Dharmacon siDESIGN® Center.

Hence, various prediction algorithms based on siRNA functionality have recently been constructed to increase the likelihood of selecting effective siRNAs, thereby reducing the experimental cost.

Recent knowledge of the genetic basis of the disease opens up the potential for cancer gene therapeutics based on siRNA.

NPs were characterized in vitro to determine the optimal formulation based on siRNA loading, controlled release profile, and mRNA knockdown.

Similarly, some studies based on siRNA mediated-invalidations suggest specific functions [ 19– 219.

To provide more confirmatory evidence, a parallel approach based on siRNAs was undertaken.

Up to now, we have resolved the crystal structure of PI4KIIα (Zhou et al., 2014) and subtype-specific PI4KIIα inhibitor candidates based on rational design are currently screened for mimicking the effects observed here for PI4KIIα siRNA knockdown.

(B ) Classifier based on cilia siRNA screen and centriole siRNA screen features only.