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This was done both by constructing distance trees based on pairwise Z-scores for structure similarity and deriving the most parsimonious tree based on shared structural features (see Table 1 for major structural features).
Toll-family proteins are defined based on shared structural features [ 21].
The transcripts were categorized based on shared structural elements and/or inferred function.
The P-loop NTPases can be phylogenetically sorted into several families based on shared structural and sequence features.
Within each class, TEs are further classified into orders, superfamilies, and families based on shared structural features and overall sequence similarity [ 8, 9].
Thus, a functionally characterized lncRNA (reference) can be used to infer the function of others that are functionally unknown (target), based on shared structural motifs.
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Similarly, there are currently no known pir homologs in P. falciparum, although rif/stevor has been suggested as related gene family based on shared sequence motifs and secondary structural features [ 20].
The unexpected RNA secondary structural similarities detected through pairwise analysis of the Rev-binding domains in HIV-1 and EIAV prompted us to generate a computational RNA structural motif model based on shared features of the two regions using RNAMotif [52].
Following the primary reconciliation of metabolites sharing structural similarity (i) or chemical nomenclature (ii), and the subsequent initial matching of reactions based on shared metabolites (iii) and/or cross-references (iv), both MNXref and MetRxn apply iterative procedures that utilize information on reaction context to increase the number of reconciled metabolites.
Based on a shared structural core of diarylamine in several known anticancer drugs as well as a new cytotoxic hit 6-chloro-2- 4-cyanophenyl)amino-3-nitropyridine (7), 30 diarylamines and diarylethers were designed, synthesized, and evaluated for cytotoxic activity against A549, KB, KB-vin, and DU145 human tumor cell lines (HTCL).
An empirical approach to investigating the functions of plant NTMC2 genes and animal FAM62 genes would therefore seem more wise than attempting to make functional predictions based on their shared structural domains, which are not homologous.
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based on shared democratic
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based on shared geographic
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based on shared common
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based on shared patterns
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based on shared regions
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