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42 In our study we delineated an expanded phenotype of degenerative disease based on shared clinical features and de novo mutations of KIF1A.
Molecular diagnostics can resolve locus heterogeneity underlying clinical phenotypes that may otherwise be co-assigned as a specific syndrome based on shared clinical features, and can associate phenotypically diverse diseases to a single locus through allelic affinity.
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Case definitions, especially when little is known about the disease, are often inductive and based on shared readily observable clinical characteristics [9].
The latter forms the basis for the construction of a disease network, based on shared MalaCards annotations, embodying associations based on etiology, clinical features and clinical conditions.
Why? Common purpose based on shared values.
We constructed a miRNA-miRNA network based on shared targets.
These relations were based on shared interests and reciprocity.
Our shares include the terrace space, and our maintenance is based on the number of shares.
And even if there should be an increased prevalence of ADHD in ED individuals [ 5- 7, 13], the relation between these two disorders might be less straightforward and more complex than expected based on clinical features shared by both disorders.
Based on this shared pathogenetic mechanism and clinical overlap, these diseases have been grouped into a single family, which has been termed the Ras-MAPK syndrome, alternatively the RAS-opathies.
Since a clinical judgement based on a shared interdisciplinary evaluation appears to be the best available option to respect ethico-legal obligations to assess patient capacity, a sound understanding of consent and its accurate evaluation in practice should form part of pre and postgraduate training.
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