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In 2004 2005, we therefore conducted a national survey among DUs who resided in metropolitan France (the ANRS-Coquelicot study) to assess the prevalence of HIV and HCV infections based on serum testing, the frequencies of at risk practices, and the risk factors for HCV prevalence.
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Multiple non-invasive tests based on serum protein glycomics have been developed for monitoring liver fibrosis (GlycoFibro test), detecting liver cirrhosis (GlycoCirrho test), and for screening HCC (GlycoHCC test).
For example, Petricoin and Liotta (2003) and Petricoin et al. (2002) have demonstrated a diagnostic screening test based on serum protein patterns for early detection of ovarian cancer.
In addition, it is difficult to provide positive and negative predictive values for the test based on serum 1,5-AG measurements.
Thus far, many tests based on serum biomarkers correlate fairly well with the fibrosis stage when advanced fibrosis (METAVIR F3-4) is compared to mild or no fibrosis (F0 to 2), but lack resolution in the intermediate stages.
The exact number of positive and negative sera used for sensitivity and specificity calculations per assay with statistical testing agreement calculations based on serum numbers is listed in Table 1.
A laboratory test to estimate GFR based on serum cystatin C levels has been developed recently.
Second, the main measure of renal function in this study was estimated GFR based on serum concentrations of creatinine, and not on independently verified clearance of an exogenous test molecule.
Thyroid function was defined based on serum TSH levels.
MMF doses were not adjusted based on serum MPA levels.
Evaluation of thyroid function was based on serum thyroid hormones.
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